The science of decreased dopamine receptors leading to brain dysfunction is poorly understood. Dr. Burns project will focus on the negative effects of dopamine depletion, which results in the characteristic brain-wide network dysfunction found in neurodegenerative disease and movement disorders, leading to symptoms such as tremors, cognitive and behavior changes, and decreased executive functions. Dr. Burns proposes that stimulation of the prefrontal cortex could be a useful treatment for patients suffering from these behavioral deficits.
This research is funded by the McKnight Brain Research Foundation through the American Brain Foundation and the American Academy of Neurology. Dr. Burns will conduct his research at the University of Florida.