A wide variety of studies have shown the role lipids – a category of fatty structures in cells – play in the progression of ALS. Dr. Lee’s project will seek to identify lipidome biomarkers that are associated with faster disease progression, and will examine whether serum lipidome and lipoprotein composition are significant predictors of ALS. This research could point to metabolic alterations and nutritional deficits that could help to explain why ALS progresses more quickly in some patients.
This research is funded by the CReATe Consortium and the American Brain Foundation, in collaboration with the American Academy of Neurology. Dr. Lee will conduct his research at Columbia University Medical Center.