Eva Klinman, MD, PhD

2023 MCKNIGHT CLINICAL TRANSLATIONAL RESEARCH SCHOLARSHIP IN COGNITIVE AGING AND AGE-RELATED MEMORY LOSS

Title/Institution: Movement Neurology Fellow, Washington University in St. Louis

Project Title: “Evaluation of age-associated changes in neuronal health and resiliency in directly converted human neurons”

Neurodegenerative conditions associated with aging, including Alzheimer’s and Parkinson’s diseases, have been studied for years. However, we still do not understand the underlying mechanisms that make the aging brain prone to degeneration. 

Dr. Klinman’s project will look at neurons, directly converted from skin cells, from old and young individuals to identify age-related changes in the structures and machinery inside cells that may predispose the aging brain to the development of neurodegenerative diseases and identify possible targets to rejuvenate old neurons.