Ryan Schubert, MD

Read about Ryan Schubert, MD

The Burden of Multiple Sclerosis:
Currently, it is difficult to determine whether a patient suffering from a first demyelinating event will or will not go on to develop relapsing Multiple Sclerosis. This is important because patients who go on to develop relapsing MS are much more likely to benefit from ongoing monitoring and treatment. The current way of determining risk of conversion to relapsing MS after a first demyelinating event is to measure MRI parameters and to use a test first developed over fifty years ago to look for the presence or absence of spinal fluid antibodies called oligoclonal bands. These are qualitative assays in need of updating in the era of precision medicine.

Our Plan to Help:
Dr. Schubert hopes to increase the accuracy of current diagnostics in MS by personalizing spinal fluid antibody testing. This will help clinicians decide how best to treat and monitor their patients. A necessary step to achieving this goal, and an improvement over other research efforts to identify high-risk patient subsets, will be Dr. Schubert’s comprehensive identification of the host target and viral trigger antigens in MS. If successful, this project would lead to the development of more precise spinal fluid diagnostics in MS while simultaneously identifying the targets and triggers of the immune response in patients with MS.

The Potential Impact of  the Results:
The results could help people who have suffered a first demyelinating event make more informed decisions about the monitoring and treatment of their condition. Dr. Schubert expects that within two years from the start of this project he will have sufficient statistical power to determine whether or not his test can accurately diagnose MS. At the same time, the results would have immediate impact on the scientific community because it will for the first time comprehensively identify the host target and viral trigger antigens in patients who have suffered a demyelinating event. These data will shed light on the etiology and pathogenesis of MS and provide leads for future investigations.