Utility of very fast electrical events in epilepsy

Very fast electrical events called high-frequency oscillations (HFOs) is closely related to the generation of epilepsy in the brain, and it may be utilized as a key signature for evaluation of epilepsy that does not respond to medication therapy.

Hiroki Nariai, MD Epilepsy-Seizure Disorders July 11, 2018 at 7:25 am


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Project Description

What We Know:
Epilepsy is one of the most common childhood neurologic conditions, and is associated with significant functional and physical disability. Recent studies suggested very fast electrical events called high-frequency oscillations (HFOs) may be closely related to the generation of epilepsy in the brain.

Our Plan to Help:
In this study, Dr. Nariai's team will identify and analyze the HFOs as children undergo epilepsy surgery, and as being evaluated for epilepsy during Epilepsy Monitoring Unit admission at UCLA. The HFOs will be sampled from direct brain recordings as well as from routine scalp electroencephalogram (EEG). The analysis data including its location and frequency will be correlated with brain imaging studies, including magnetic resonance imaging (MRI) and positron emission tomography (PET), and with seizure outcome. This is the first study to include all stages of epilepsy in children to investigate HFOs. The results may provide new insights into a biomarker that could be of value in determining which brain region to take out during epilepsy surgery, and assessing children at risk for developing drug-resistant epilepsy in the future. Dr. Nariai will also be able to accumulate enough data to evaluate how these high frequency activities express themselves as a function of brain development.

How You Can Help:
Donate to Dr. Nariai's research project to help those with epilepsy.

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Campaign Ends on January/29/2019