Fibromyalgia is a chronic condition that causes muscle pain and tenderness throughout the body, fatigue, difficulty sleeping, and mood issues. People with fibromyalgia may have a heightened sensitivity to pain compared to people without fibromyalgia. Because fibromyalgia is a chronic pain condition that does not result from actual damage to the nerves and muscles, researchers are investigating possible autoimmune and inflammation-based causes.
Approximate number of U.S. adults with fibromyalgia
Women are twice as likely as men to develop fibromyalgia
Percent of people with fibromyalgia who have depression and/or anxiety
The cause of fibromyalgia is unknown. Research shows that people with fibromyalgia may have changes in their brain and spinal cord that affect how their brain and nerves transmit signals from the body and process pain. Fibromyalgia does not actually damage the nerves themselves. Changes in the brain and nervous system could also contribute to the common fibromyalgia symptoms of fatigue and sleep issues.
For some people, symptoms begin after a triggering event like physical or emotional trauma, surgery, or infection. For others, symptoms gradually occur over time without any specific trigger.
Fibromyalgia can affect people of all ages, including children, but symptoms usually begin in middle age. The risk of developing fibromyalgia increases with age. The disorder tends to run in families, so there may be a genetic link, but people with no family history of fibromyalgia can also develop symptoms.
Researchers believe non-genetic factors—such as having lupus, rheumatoid arthritis, a mood disorder, or another condition that causes pain—could play a role in developing fibromyalgia. It may also be linked to sleep issues, stress, and immune, endocrine (hormonal), or biochemical problems.
The most common symptoms of fibromyalgia are pain throughout the body (often in the arms, legs, head, chest, abdomen, back, and buttocks), fatigue, and sleep issues. Pain usually affects the muscles, as well as the ligaments and tendons that connect muscles to bones. Some people describe their pain as a constant, dull ache, but for others it can feel like burning or throbbing.
People with fibromyalgia may also have muscle and joint stiffness, tenderness to touch, headaches, and sensitivity to light, sound, and smells. In some cases, pain and heightened sensitivity may be accompanied by problems with thinking clearly, concentration, and memory (often known as “fibro fog”).
Other symptoms include tingling or numbness in the hands and feet, facial or jaw pain (including temporomandibular joint syndrome, or TMJ), depression, anxiety, and digestive issues such as bloating, constipation, and irritable bowel syndrome.
Fibromyalgia can cause disability, a lower quality of life, and an increased risk of hospitalization, depression, and other types of arthritis and rheumatic conditions.
The main standard for a fibromyalgia diagnosis is widespread pain in at least four of five areas of the body for at least three months. These five areas include the right and left upper regions, right and left lower regions, and the axial region (neck, back, chest, and abdomen).
A doctor will typically diagnose fibromyalgia through a physical examination, medical history review, X-rays, and blood tests. Blood tests can help rule out other conditions.
There is no cure for fibromyalgia, but pain and other symptoms can be managed with medication and certain lifestyle changes. Many people work with a rheumatologist, a doctor who specializes in treating fibromyalgia and other types of arthritis.
Drug treatments may include prescription and over-the-counter medications, such as pain relievers, anti-inflammatory medicines, antidepressants, and anti-seizure drugs.
People with fibromyalgia can also reduce pain and improve symptoms with regular exercise, healthy sleep habits, and stress management activities like yoga, meditation, acupuncture, and massage. Patient education classes, physical and occupational therapy, and cognitive behavioral therapy (CBT) can also provide individuals with tools and strategies to minimize symptoms and manage the psychological and emotional burden of the disorder.
Current research is focused on better understanding fibromyalgia and its causes, as well as finding more effective ways to diagnose, treat, and ultimately cure the disorder. Some clinical trials are investigating different treatment options for pain management, including neurostimulation like vagus nerve stimulation, which has been FDA-approved to treat certain forms of epilepsy and depression. There are also clinical trials underway to evaluate the effectiveness of Neurotropin, a drug that has been used in Japan to treat chronic pain conditions, including fibromyalgia.
National Institutes of Health: Fibromyalgia
Johns Hopkins Medicine: Fibromyalgia
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