Because Batten disease is associated with different gene mutations, symptoms can vary in severity and progress at different rates. The most common signs of Batten disease include progressive vision loss that leads to blindness, seizures, movement issues, cognitive decline, and dementia. Other symptoms include sleep disturbances and changes in mood, personality, and behavior.
Children with Batten disease will often not meet developmental milestones for standing, walking, and talking, and in some cases they may lose these skills over time. They may also experience learning difficulties, trouble concentrating, and progressive loss of speech and language.
Rarely, symptoms begin in adulthood. In those cases, vision is not affected and symptoms may be more mild.
Symptoms worsen as the disease progresses, leading to cognitive problems, more severe seizures, and loss of sight and motor skills. Eventually, individuals with Batten disease become unable to see, move, or communicate.