Alzheimer’s disease is an age-related, irreversible brain disorder that develops over a period of years. Alzheimer’s is the most common cause of dementia, a group of disorders characterized by cognitive and behavioral problems. Other types include frontotemporal dementia, Lewy body dementia and vascular dementia.
These conditions are marked by a progressive loss of functional capacity and independence and impose an immense personal and societal burden. Genetic, environmental or lifestyle factors play a role in causing the diseases, with genetics appearing to play a larger role in some of the early-onset dementias.
Treatment trials and diagnostics are ongoing for Alzheimer’s and other types of dementia. There are currently no cures.
How do Tau and Amyloid interact to cause Alzheimer’s dementia?
What therapeutic targets are suitable candidates for treatment strategies?
Can we predict who will get dementia?
Can we prevent dementia by treating individuals before they show symptoms?