Our Researchers

The American Brain Foundation supports world class research on cutting edge projects. Funding research across a broad spectrum of the brain and nervous system is the best hope for curing brain disease as a whole.

Juneyoung Lee, PhD

What We Know: Elderly patients with acute stroke may succumb to post-stroke infection (PSI), rather than the brain injury itself. Studies have revealed that the gut is an epicenter of PSI contributing to worsened outcomes and morbidity. Stroke is a leading cause of mortality in elderly individuals and is also a major public health issue for patients and their families.read more

William Mantyh, MD

What We Know: Little research has been done exploring how Alzheimer’s disease can develop at such an early age, and why it can produce different symptoms than late onset Alzheimer’s disease. For instance, rather than having the typical memory problems of late onset Alzheimer’s disease, patients with early onset Alzheimer’s disease can have symptoms referable to brain areas responsible for visual,read more

Suma Babu, MD

What We Know: It is known from pre-clinical studies that inflammatory cells called “glia” are activated in brains and spinalcords of people with Amyotrophic Lateral Sclerosis (ALS) and may play a role in disease progression. Our Plan to Help: Dr. Babu’s goal is to understand the inflammatory and neurodegenerative changes in the spinal cords of people living with ALS. Dr.read more

Shruti Raja, MD

What We Know: Autoimmune myasthenia gravis (MG) is a debilitating and potentially fatal disease characterized by fatigable weakness of ocular, bulbar, respiratory and limb muscles. Current surgical and medical management of MG varies across centers, and the generalization of clinical trial data to the overall MG population is unclear. Questions regarding which commonly used therapies are most effective in treatmentread more

Jennifer Vermilion, MD

What We Know: Chronic tic disorders (CTDs) such as Tourette syndrome are common, affecting approximately 1% of youth. Anxiety disorders are present in the majority of youth with tic disorders but the types of anxiety symptoms and the impact of these symptoms in youth with tic disorders are not well understood. Tics often improve by young adulthood, but anxiety tendsread more

Sanaz Sedaghat, PhD

What We Know: Patients with kidney disease develop brain disorders more rapidly and frequently than the general population. Their kidneys are unable to efficiently clear metabolic toxins from their body. This inadequate removal of toxins can damage neurons and supporting cells in the central and peripheral nervous system leading to brain dysfunction. Our Plan to Help: Dr. Sedaghat’s research aimsread more

Kevin Keenan, MD

What We Know: Currently minimally invasive surgery to treat large artery strokes can only be done at special hospitals. The treatment is quite beneficial but also very time sensitive. Sometimes patients are not eligible for treatment because it takes too long to transfer them from a hospital without the treatment to one with the treatment. Our Plan to Help: Dr.read more

Anna Goodheart, MD

What We Know: Parkinson’s disease and Lewy body dementia are neurodegenerative diseases that affect millions of people and for which there are currently no cures. The cause of damage to neurons in these diseases is not well understood, but we do know that a number of molecular changes are occurring within the cells. In the past, it wasn’t possible toread more

Reza Seyedsadjadi, MD

What We Know: Despite recent improvements in the understanding of disease processes, researchers have not been able to identify sensitive and reliable outcomes to capture and predict potential response to treatments in hereditary neuropathies, including the most common type Charcot-Marie-Tooth (CMT) Type 1A. The current outcome measures are not sensitive enough to detect subtle changes in disease status, requiring largeread more

Lisseth Burbano, MD

What We Know: The KCNT1 gene encodes a protein that forms a sodium-activated potassium channel. This channel is widely expressed in the nervous system and has a role in the regulation of neuronal communication. Mutations in the KCNT1 gene can produce a severe neurological condition with epilepsy and cognitive impairments. These mutations cause considerably higher levels of channel activity whichread more

Ulrike Kaunzner, MD

What We Know: Despite new treatments, the majority of multiple sclerosis (MS) patients still develop disease progression. There is currently no measure available to predict MS disease progression. Our Plan to Help: Chronic or old MS lesions can be separated into chronic inactive and chronic active lesions. Chronic inactive lesions are scars that are not changing over time. Chronic activeread more

Omar Al-Louzi, MD

What We Know: There is an imaging finding in patients with multiple sclerosis (MS) called the “central vein sign” (CVS), which is the appearance of a central blood vessel, presumed to be a small vein that travels through the center of lesions. Lesions demonstrating CVS appear to be more frequent in patients with MS compared to other disorders that can causeread more

David Coughlin, MD

What We Know: Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are caused by pathological clusters of the protein alpha-synuclein that deposit throughout the brain. These two diseases also display similar motor function features like tremor, rigidity, and slowness of movement and also cognitive features of visual hallucinations and fluctuations in attention. Because of these similarities, they are collectivelyread more

Faisal Amin, MD, PhD

What We Know: Post traumatic headache (PTH) is an increasing problem among the younger population. Unfortunately, not much is known about why some patients develop PTH and even less is known about how to treat this invalidating condition. Our Plan to Help: Dr. Amin’s research will focus on the imaging biomarkers of post traumatic headache which is the first stepread more

Christian Camargo, MD

What We Know: As we get older certain aspects of thinking and processing information are not as sharp as when we’re younger. For example, your ability to remember and recall certain information decreases. This decreased memory happens naturally, and affects some people more than others – in fact, some people may never feel like their memory declined. Others may findread more

Jennifer Marsella, MD

What We Know: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease affecting nerve cells in the brain and spinal cord that is often fatal within five years, most commonly due to respiratory failure because of weakened respiratory muscles. The use of non-invasive ventilation, which is pressurized air delivered through a mask, prolongs survival and improves quality of life forread more

Brian_Appleby,_MD_crowd_researcher

Brian Appleby, MD

What we Know: Prion disease is fatal in 100% of people who are affected, and there is no treatment currently available. In the months leading up to death, those suffering from prion disease can lose their memory and cognitive ability, become depressed and weak, lose control of their movements, go blind, and face increased risk of infections such as pneumonia.read more

Hiroki Nariai, MD

Hiroki Nariai, MD

What We Know: Recent studies suggested very fast electrical events called high-frequency oscillations (HFOs) may be closely related to the generation of epilepsy in the brain. Dr. Nariai will identify and analyze the HFOs as children undergo epilepsy surgery. Results of this research may lead to new insights into a biomarker that could be of value in determining which brainread more

Kanika Sharma, MD headshot

Kanika Sharma, MD

Overview: Multiple sclerosis (MS) is a challenging neurological disorder in which the immune system targets the specialized myelin covering of nerve fibers, causing abnormal alteration in neural communication. Patients with MS are debilitated and often have fatigue, seizures, paralysis, depression, and other serious symptoms. Dr. Kanika Sharma, of the University of Iowa, hopes to improve outcomes and reduce costs forread more

Bhavana Patel, MD

Bhavana Patel, MD

What We Know: Dementia with Lewy bodies (DLB) is a very common cause of memory problems in the United States. It is often not properly identified and at this time we do not know enough about whether people with DLB are accessing the best care for their disease. Our Plan to Help: Dr. Patel’s team will look at various aspectsread more

Wissam Georges Deeb, MD

Wissam Georges Deeb, MD

What We Know: Tourette syndrome is a common condition that causes multiple tics. Tics can be unwanted body movements and sounds. For some patients, tics are bothersome and can limit the activities and opportunities in their lives. Treatment is sometimes needed. When a doctor starts a treatment, they need to know if tics are getting better. For this reason, doctorsread more

Davut Pehlivan, MD

Davut Pehlivan, MD

Overview: Patients with neuromuscular disorders, such as Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis, experience significant consequences as a result of these diseases. However, many other neuromuscular disorders (NMDs) are less well known but still have severe consequences for the people experiencing them. Dr. Duvat Pehlivan, of Baylor College of Medicine, in Houston, Texas, is trying to findread more

Emily Harrington, MD, PhD

Emily Harrington, MD, PhD

What We Know: Oligodendrocytes are the cells in the central nervous system that wrap neurons with myelin sheaths and allow for rapid conduction of action potentials. Oligodendrocytes have many roles other than wrapping axons including communicating with neurons through synapses. A largely unexplained role of oligodendrocyte progenitors is how they interface and interact with immune cells and how these interactionsread more

Katharine Nicholson, MD

Katharine Nicholson, MD

What We Know: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting primarily the motor neurons and causing weakness, paralysis and usually death from respiratory failure. Familial or inherited ALS accounts for about 10% of all ALS and is most commonly caused by a genetic mutation called the C9ORF72 (C9) repeat expansion. There are many asymptomatic individuals in families affectedread more

Kimberly Albert, PhD

What We Know: Memory is a complex process that relies on a number of other cognitive functions including attention. In order for information to make it into memory, attention must be directed toward the information to be remembered. Memory changes that are identified in aging may be the result of earlier changes in attention. Additionally, memory and attention processes occurread more

Brice McConnell, MD, PhD

What We Know: Transcranial electrical stimulation has been demonstrated to enhance slow wave sleep activity, and to modulate sleep quality and cognitive performance when applied during non-rapid-eye-movement sleep in young adults, aging adults, and adults with mild cognitive impairment. Despite promising preliminary results with transcranial electrical stimulation, significant gaps remain to be filled before we will be able to reliablyread more

Sunil Sheth, MD

What We Know: Stroke is a devastating disease that can leave its victims severely disabled. It is often caused by a blood clot that lodges in a blood vessel of the brain, and in the last few years tremendous strides have been made to develop new treatments that remove the culprit blood clot with minimally invasive techniques. These treatments wereread more

Peter Creigh, MD

What We Know: Amyotrophic Lateral Sclerosis (ALS) is a devastating disease. Unfortunately, there are still only two approved treatments for ALS and neither is very effective. More research is needed to discover new therapies. Participating in studies at research centers can be difficult for people with ALS due to problems with mobility, travel, and caregiver burden. “Virtual” research visits fromread more

Xiaoyan Jiang, PhD

What We Know and Our Plan to Help: Dr. Jiang’s research can lead to a novel therapy for promoting DNA repair and neuronal recovery after stroke. The long-term significance of her research is to identify a new type of therapy that could be used alone or in conjunction with current stroke treatments and improve the quality of life for strokeread more

Johanna Hamel, MD

Johanna Hamel, MD

What We Know: Myotonic dystrophy is the most common adult onset muscular dystrophy. There is currently no available disease modifying treatment. Current theories hold that the genetic defect causes a toxic RNA, which accumulates in the nucleus of the cell and causes protein dysfunction by trapping proteins important for normal cell function. However, this may not be the complete explanation,read more

Jill Napierala, PhD

Jill Napierala, PhD

What We Know: Friedreich’s ataxia (FRDA) is a severe and progressive neurodegenerative disorder caused by lower production of the frataxin protein.  Its deficiency leads to complex changes in multiple organs of FRDA patients, with neurons and heart cells being most affected by lower levels of frataxin.  As all functions of an organism are interconnected, the deficiency of a single, criticalread more

Michelle Fullard, MD

Michelle Fullard, MD

What We Know: As Parkinson’s disease progresses, patients can develop motor fluctuations in which they alternate between periods of ON time, when Parkinson’s medications are improving symptoms of slowness, tremor and stiffness, and periods of OFF time, when the Parkinson’s symptoms return. Dyskinesias, or excessive movements, can also occur. Our Plan to Help: The goals of this study are toread more

Laura Graham, MPH

Laura Graham, MPH

What We Know: Weight management programs are designed to reduce cardiovascular risk factors. In addition to weight loss, participants also expect to improve long-term cardiovascular health. However, current research does not show an effect of these programs on long-term cardiovascular outcomes such as stroke or acute myocardial infarction. Our Plan to Help: Dr. Graham believes that this is due toread more

Joel Salinas, MD, MBA, MSc

Joel Salinas, MD, MBA, MSc

Overview: No biological factors completely explain the patterns of Alzheimer’s disease risk, though recent evidence suggests socio-behavioral influences are linked with accumulation of Alzheimer’s disease pathology. These influences, which we might be able to improve, remain unexplained—likely due to the current lack of tools for measuring these social influences which might be harnessed for Alzheimer’s disease interventions. Our Plan toread more

Alice Lam

Alice Lam, MD, PhD

The Research: The goal of Dr. Lam’s research is to develop new, non-invasive tools to identify and understand the role of epilepsy in Alzheimer’s disease The Potential Impact of the Results: Dr. Lam will be developing new approaches for detecting epilepsy and other forms of abnormal brain activity in people with Alzheimer’s disease.  This work will lead to a betterread more

Eugene_Scharf,_MD_crowd_researcher

Eugene Scharf, MD

Overview: Stroke is a leading cause of death and disability in the United States, often leaving victims significantly impaired and unable to work or go about activities of daily living. The endocannabinoid system is a natural healing mechanism within the body, and research suggests that it may play a role in protecting neurologic function in patients who suffer a stroke.read more

Professor_Steffen_Jung_crowd_researcher

Professor Steffen Jung, PhD

What we Know: Over 5 million Americans suffer from Alzheimer’s disease, while 3 million have inflammatory bowel disease, and over 400,000 have multiple sclerosis. Other inflammatory diseases, such as asthma and arthritis, impact many more millions of American lives. These are grim figures in the face of a significant lack of effective treatments for some of these conditions. In addition,read more

Ryan_Schubert,_MD_crowd_researcher

Ryan Schubert, MD

The Burden of Multiple Sclerosis: Currently, it is difficult to determine whether a patient suffering from a first demyelinating event will or will not go on to develop relapsing Multiple Sclerosis. This is important because patients who go on to develop relapsing MS are much more likely to benefit from ongoing monitoring and treatment. The current way of determining riskread more

Miguel_Fiol,_MD_crowd_researcher

Miguel Fiol, MD

What we Know: Glioma is a brain tumor formed when glia – supportive cells that protect neurons in the brain – become cancerous. Gliomas make up more than two thirds of tumors originating in the brain. As these tumors grow, they damage important nearby brain tissues, causing a range of symptoms including headaches, unsteadiness, cognitive impairment, seizures and personality changes.read more

Manav_Vyas,_MD_crowd_researcher

Manav Vyas, MD

There are over 300 million immigrants and refugees in the world today, many millions of whom live in the United States and Canada. Dr. Manav Vyas, of the University of Toronto, and a team of researchers want to find out how immigration status affects care and outcomes after stroke, a leading cause of death and disability around the world.

A._Gordon_Smith,_MD,_FAAN_and_his_team_crowd_researcher

A. Gordon Smith, MD

More than 40,000 women will die of breast cancer this year. Many of the most effective chemotherapy drugs for treating breast cancer cause serious side effects, including peripheral neuropathy, which causes numbness, pain and difficulty walking. Neuropathy is one of the most common reasons for stopping chemotherapy, potentially reducing the success of treatment. Neuropathy often drastically reduces quality of life. Drs Gordon Smith, Kelsey Juster-Switlyk and Summer Karafiath of the University of Utah plan to find out what causes neuropathy, so that we can prevent it and get patients the treatment they need and improve their quality of life.

James_Noble,_MD_crowd_researcher

James Noble, MD

Sports-related concussions are often missed or disregarded in young athletes. Competitive pressures may drive children to continue playing after having a concussion. Delayed recognition can cause serious neurological problems including chronic headaches, memory lapses, learning difficulties, and even permanent disability if two or more concussions occur in close succession. Dr. James Noble, of Columbia University, plans to create an interactive educational activity to improve concussion awareness and reduce long-term brain damage in young athletes.

J._Kent_Werner,_MD_crowd_researcher

J. Kent Werner, MD

Alzheimer’s disease and other neurodegenerative disorders including Frontotemporal dementia (FTD), Dementia with Lewy bodies(DLB), Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and progressive supranuclear palsy (PSP) are some of the most devastating afflictions faced by individuals, their families, and our society. There is no cure available for these neurodegenerative conditions. Dr. Werner and his team at Cogentis Therapeutics are developing groundbreaking therapies to reverse these disorders in collaboration with the NIH, Harvard Medical School, MIT, and Johns Hopkins University.

Charlene_Ong,_MD_crowd_researcher

Charlene Ong, MD

Brain swelling is a potentially lethal complication of acute brain injuries. Current methods of detecting brain swelling are invasive, or may identify its progression too late to reverse further damage. Dr. Charlene Ong of Harvard University will test whether an innovative handheld technology that measures pupil changes can improve the diagnosis and treatment of brain swelling. Her findings could save lives and improve quality of life for those who suffer from sudden and catastrophic brain injuries.

Ania_Busza,_MD_crowd_researcher

Ania Busza, MD, PhD

Stroke is one of the leading causes of death and disability in the United States, often leaving victims unable to speak, climb the stairs, or go to work. Rehabilitation can help these victims get back to their normal lives, but many patients become discouraged and fail to get the most out of their treatment. Dr. Ania Busza, of the University of Rochester, hopes to improve stroke rehabilitation by using a high-tech virtual reality device to engage stroke victims during rehab sessions and motivate them to continue their treatment.

Adam_Mecca,_MD,_PhD_crowd_researcher

Adam Mecca, MD, PhD

Alzheimer’s disease is the number one cause of dementia worldwide, and currently no treatments can stop it. In Alzheimer’s disease, memory defects are caused by the loss of connections between brain cells. Dr. Adam Mecca, of Yale University, plans to use a high-tech imaging system to find out when this disconnection happens, which may help improve the use of current treatments and aid the discovery of new drugs to fight Alzheimer’s disease.

Aaron_Boes,_MD_crowd_researcher

Aaron Boes, MD

As if having brain cancer isn’t devastating enough for a child and his family, about one in four children with brain cancer of the cerebellum also develop a condition known as posterior fossa syndrome. This syndrome involves problems with speech and movement, similar to the symptoms a stroke victim might experience. The cause of posterior fossa syndrome, however, is unknown. Working alongside doctors at Harvard’s Massachusetts General Hospital, Dr. Aaron Boes plans to study why these problems occur, so that children already suffering from brain cancer, may not also have to deal with these complications.

Kevin_Sheth,_MD,_FAHA,_FCCM,_FNCS,_FAAN,_FANA_Researcher

Kevin Sheth, MD, FAHA, FCCM, FNCS, FAAN, FANA

Project goal: Use methods to detect early brain swelling of patients with devastating brain injury, and test new drugs to prevent further swelling.

Holly_Hinson,_MD_Researcher

Holly Hinson, MD

Project goal: Develop a scale to describe or quantify the severity of a syndrome some patients with traumatic brain injury (TBI) develop called “Paroxysmal Sympathetic Hyperactivity” (PSH).

Ana-Claire_Meyer,_MD_Researcher

Ana-Claire Meyer, MD

Project goal: Expand access to and improve the quality of neurological care both domestically to underserved populations and globally to underserved regions.

Paul_George,_MD,_PhD_Researcher

Paul George, MD, PhD

Project goal: Develop treatments to restore lost brain function after stroke.

An_Hong_Do,_MD_Researcher

An Hong Do, MD

Project goal: Discover a new therapy approach that can provide stroke survivors with improvements exceeding those of typical rehabilitation therapies.

Jeffrey_Gelfand,_MD_Researcher

Jeffrey Gelfand, MD, MAS

Project goal: Improve care for patients with neurosarcoidosis, an inflammatory disease involving the nervous system, by identifying less invasive ways to diagnose the disease, optimizing neuroimaging (MRI) to detect the characteristic pattern of inflammation that marks sarcoidosis and discover better treatments.

Stefanie_Geisler,_MD_Researcher

Stefanie Geisler, MD

Project goal: In hopes of finding ways to keep peripheral nerve fibers alive during chemotherapy treatments, the research investigated whether nerve fibers can be protected by removing or interfering with a certain protein associated with nerve fiber death.

Vikram_Khurana,_MD,_PhD_Researcher

Vikram Khurana, MD, PhD

Project goal: Identify abnormalities of cells from patients with Parkinson’s and other neurodegenerative diseases in hopes of developing a personalized neurology approach to these disorders.

Ricardo_Roda,_MD,_PhD_Researcher

Ricardo Roda, MD, PhD

Project goal: Identify new antibodies in myasthenia gravis and how they cause disease.

Nada_Hindiyeh,_MD_Researcher

Nada Hindiyeh, MD

Project goal: Develop a screening tool for the diagnosis of chronic migraine.

Lidia_Maria_Moura,_MD_Researcher

Lidia Maria Moura, MD

Project goal: Study the impact of how physicians deliver care to patients with epilepsy and to redesign care delivery so that the individual goals and needs of the patient drive positive outcomes and define quality rather than traditional process measures.

Elissaios_Karageorgiou,_MD_Researcher

Elissaios Karageorgiou, MD

Project goal: Use magnetoencephalography to identify biomarkers in the brain to help accurately diagnose Frontotemporal Lobar Degeneration (FTLD).

Suzanne_Goh,_MD_Researcher

Suzanne Goh, MD

Project goal: Use magnetic resonance imaging (MRI) to identify features of the brain, such as neural signatures or biomarkers, to help diagnose Autism Spectrum Disorders (ASD).

Padmaja_Vittal,_MD,_MS_Researcher

Padmaja Vittal, MD, MS

Project goal: The goal of this research is to evaluate different genetic patterns in patients with Fragile X-associated tremor/ataxia syndrome (FXTAS).

Randall_Bateman,_MD_Researcher

Randall Bateman, MD

Project goal: Investigate different biomarkers, or laboratory tests, to determine ways to predict who will be affected by Alzheimer’s disease before they have symptoms of it.

Hristelina_Ilieva,_MD,_PhD_Researcher

Hristelina Ilieva, MD, PhD

Project goal: Determine how different glial cells and neurons are affected in the most common subtype of familial ALS – the C9ORF72 linked ALS.

Jonathan_Lipton,_MD,_PhD_Researcher

Jonathan Lipton, MD, PhD

Project goal: To understand the biological basis for sleep disturbance in patients with neurodevelopmental diseases such as autism.

Salim_Chahin,_MD_Researcher

Salim Chahin, MD

Project goal: Discover new methods to measure and investigate the cause of fatigue, a common and disabling symptom in multiple sclerosis (MS).

JÖRG_DIETRICH,_MD,_PHD_researcher

Jörg Dietrich, MD, PhD

Project goal: Find possible ways to repair structural and functional damage to the brain caused by chemotherapy and radiation.